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Bisphosphonates: Overprescribed?

They increase in popularity on a daily basis: in fact, Fosamax was prescribed over 22 million times in 2005. They are touted as a miracle drug for the treatment and prevention of thinning and weakening bones (osteoporosis). But given recent revelations of bisphosphonate side effects, including bone death, are bisphosphonates overprescribed?

Growing Market, Growing Popularity

The population is aging as baby boomers become older Americans. As a result, bisphosphonates such as Zometa, Fosamax, Aredia, Boniva, and Actonel have taken center stage as the cure for treatment and prevention of weakening bones (osteoporosis), especially in postmenopausal women. But some are concerned over the definition of osteoporosis, which could cause overprescription of these often long-term bone density treatments. In particular, though Fosamax is often prescribed for women with osteopenia (a milder form of osteoporosis that often goes undiagnosed and untreated), it actually does not help women with this condition. Women with osteopenia can treat themselves with diet and weight-bearing exercise - an attractive option given bisphosphonate side effects. However, doctors are still prescribing bisphosphonates to these women, especially given the confusion between osteopenia and osteoporosis.

How Bisphosphonates Work

Bisphosphonates mimic pyrophosphate, a salt manufactured by our body which is key in both metabolic and bone regeneration processes. They allow bones to gain mass by inhibiting bone resorption, but studies are now showing that this process may interrupt the natural balance gained by the body in bone generation, causing a backfire in which microfractures are unable to heal after trauma, such as that incurred during dental surgery. In addition, bisphosphonates do not actually stimulate bone growth - they simply outweigh bone loss. Hence, they do not prevent fractures in women with osteopenia and no previous fractures.

The Risks of Bisphosphonates

Bisphosphonates are available in intravenous and tablet forms. The drug has been linked to side effects such as osteonecrosis of the jaw, a condition in which traumatized bone tissue fails to heal and eventually dies. There is no cure for ONJ; a May 2006 study published in the Annals of Internal Medicine found that 94 percent of the cases of ONJ occurred in patients who took bisphosphonates intravenously. In addition, bisphosphonates have been linked to other side effects such as gastrointestinal distress, severe allergic reactions, bone pain and hot flashes. Patients who are taking non-steroidal anti-inflammatory drugs (NSAIDs) should tell their doctor before beginning bisphosphonates and talk to dentists before undergoing dental surgery, which could increase the risk of ONJ.

Have You Been Affected?

If you are a patient who has been affected by bisphosphonate side effects, seek proper medical intervention immediately. Then contact an experienced attorney with expertise in unsafe drug litigation. Your bisphosphonate lawyer can evaluate your potential case and tell you if you qualify for financial restitution for expenses such as medical bills, future medical care, lost wages, and pain and suffering. An experienced bisphosphonate lawyer can help you file your claim and bring your case to settlement.

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