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Bisphosphonates Side Effects

Name: Bisphosphonates are a class of drug which include prescription forms such as Actonel, Aredia, Boniva, Fosamax, Skelid, and Zometa
Generic: Generics include alendronate

Manufacturer: Varies. Primary manufacturers include Merck (Fosamax), Proctor & Gamble (Actonel) and Roche Therapeutics (Boniva).
Date approved: Varies. The first bisphosphonates were approved in the mid-1990s.

Status: Prescription only.
Approved uses: Treatment of bone-weakening diseases including cancer, osteoporosis, and Paget's disease.
Off-Label uses: Anti-fracture uses; however, the anti-fracture properties of bisphosphonates have not been proven.
Side effects:
  • Osteonecrosis (ONJ) of the jaw ("dead jaw syndrome")
  • Femur Fractures
  • Esophageal Disorders
  • Bone Pain and Swelling
Related topics: Unsafe Drugs, Fosamax
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Bisphosphonates

Bisphosphonates are a class of drug designed to strengthen bones and include brand names Actonel, Aredia, Boniva, Fosamax, Skelid and Zometa.  They are commonly prescribed in cases of osteoporosis, bone cancer and other bone-weakening diseases.  Common side effects include rash, bone pain, and gastrointestinal symptoms; however, bisphosphonates have recently been linked to osteonecrosis of the jaw ("dead jaw syndrome"), a wasting disease in which bone tissue dies.  Experts concede that the drug is overprescribed and that the long-term effects of bisphosphonates are still unknown. 

Bisphosphonates: Overprescribed?

They are touted as a miracle drug for the treatment and prevention of thinning and weakening bones (osteoporosis). But given recent revelations of bisphosphonate side effects, including bone death, are bisphosphonates overprescribed. As a result, bisphosphonates such as Zometa, Fosamax, Aredia, Boniva, and Actonel have taken center stage as the cure for treatment and prevention of weakening bones (osteoporosis), especially in postmenopausal women. read more

Bisphosphonates Can Cause Jaw Bone Death

They are increasingly prescribed in both women and men for the treatment and prevention of thinning and weakening bones (osteoporosis). But recent studies are showing that despite their popularity, bisphosphonate drugs carry significant risks for patients who use the drugs long term, including osteonecrosis of the jaw (ONJ) and other long-term health issues. Administered in both intravenous and tablet forms, these popular bisphosphonate drugs are prescribed - some would say overprescribed - to women and men who take the drugs over a long period of time to treat and prevent osteoporosis-related bone loss. read more

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Bisphosphonates Jury Verdicts

______ VERDICT Dental malpractice alleged failure to proper insert implants, bridges and crowns loss of teeth Permanent cosmetic deformity.

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Bisphosphonates News Articles

Gazeta de Sud - 13 Aprilie 2011 » Caut medicament pentru cancer

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Bisphosphonates Newsfeeds

Reportlinker Adds Bone Metastases Therapeutics - Pipeline Assessment and Market Forecasts to 2017

European Medicines Agency Concludes Class Review Of Bisphosphonates And Atypical Fractures

View the Bisphosphonates Newsfeeds page here

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